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Keap1-mediated degradation of PGAM5 and Bcl-xL could be active in CRC plus the ratio of thioredoxin/ Keap1 protein level may be handy for suggesting distant metastasis in CRC.expression induces drug resistance (48). Irrespective of whether these inhibitors synergize with TAK-243 or enrich the synergy we observed with PARPi and C/E chemotherapy may